BIP! Finder - Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.

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2013 • Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.

Authors: Lutz Nuhn, Sebastian Hartmann, Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz

Abstract: Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.

External links: OpenAIRE

Works in BIP! associated with the specified OpenAIRE research product

Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential (...)

Lutz Nuhn, Sebastian Hartmann, Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Ho (...)

Angewandte Chemie International Edition · 2013

Combinatorial chemistry | Biochemistry |

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