2005 •
Task-dependent posterior cingulate activation in mild cognitive impairment.
Authors:
Michele L. Ries, Taylor W. Schmitz, Taylor W. Schmitz, Tisha N. Kawahara, Tisha N. Kawahara, Britta M. Torgerson, Britta M. Torgerson, Mehul A. Trivedi, Mehul A. Trivedi, Sterling C. Johnson, Sterling C. Johnson
Abstract:
Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic Mild Cognitive Impairment (MCI), a major risk factor for the development of Alzheimer’s disease (AD). In functional magnetic resonance imaging (fMRI) studies with healthy participants, this same region is active during self-appraisal (requiring retrieval of semantic knowledge about the self) as well as episodic recognition of recently-learned information. Administering both types of tasks to peopl (...)
Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic Mild Cognitive Impairment (MCI), a major risk factor for the development of Alzheimer’s disease (AD). In functional magnetic resonance imaging (fMRI) studies with healthy participants, this same region is active during self-appraisal (requiring retrieval of semantic knowledge about the self) as well as episodic recognition of recently-learned information. Administering both types of tasks to people with MCI may reveal important information regarding the role of the PCC in recollection. This study investigated fMRI activation in the PCC in individuals with MCI and age, gender, and education-matched controls across two tasks. The first task was a visual episodic recognition task in which participants indicated whether pictures had or had not been presented during a study session. The second task was an autobiographical self-appraisal task in which subjects rated themselves on a set of trait adjectives. Results of a conjunction analysis revealed the PCC as the sole region commonly active during both tasks in the healthy older adults. Furthermore, additional analysis revealed an interaction in the PCC indicating a task-dependent response in the MCI group. MCI participants showed PCC activation during self-appraisal, but not during episodic retrieval. These results suggest in MCI that the PCC shows functional degradation during episodic retrieval of visual information learned in the laboratory. In contrast, the PCC’s role in retrieval and evaluation of highly-elaborated information regarding the self is more well-preserved. (Read More)
Michele L. Ries, Taylor W. Schmitz, Tisha N. Kawahara, Britta M. Torgerson, Mehul A. Trivedi, Sterli (...)
NeuroImage ·
2006
Cognitive psychology |
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