2014 •
On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets
Authors:
Nikita Reznik, Guillaume Lajoinie, Oleksandr Shpak, Erik Gelderblom, Ross Williams, Nico de Jong, Michel Versluis, Peter N. Burns, Peter N. Burns
Abstract:
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the pres (...)
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice. (C) 2014 World Federation for Ultrasound in Medicine & Biology. (Read More)
Nikita Reznik, Guillaume Lajoinie, Oleksandr Shpak, Erik C. Gelderblom, Ross Williams, Nico de Jong, (...)
Ultrasound in Medicine & Biology ·
2014
Acoustics |
We have placed cookies on your device to help make this website and the services we offer better. By using this site, you agree to the use of cookies. Learn more