2025 •
Nano-scale morphological and chemical characterization of cardiac, coronary and carotid macro-/micro-thrombi in COVID-19 positive and negati
Authors:
Murielle SALOME, Marina ECKERMANN, Martina VENERONI, Paola COAN, Alberto BRAVIN
Abstract:
This project aims at gaining novel insight in two pathological mechanisms observed in the vascular system supplying the heart and brain of COVID-19 patients as an adverse consequence of a SARS-CoV-2 infection, i.e. the development of 1) macroscopic thrombi (MTs) in epicardial coronary and carotid arteries and 2) peripheral microscopic thrombi (��Ts) in myocardial and brain microvasculature. Few pathology studies have been conducted thus far and a precise mechanistic understanding is still needed. We propose the use of a combination of diffe (...)
This project aims at gaining novel insight in two pathological mechanisms observed in the vascular system supplying the heart and brain of COVID-19 patients as an adverse consequence of a SARS-CoV-2 infection, i.e. the development of 1) macroscopic thrombi (MTs) in epicardial coronary and carotid arteries and 2) peripheral microscopic thrombi (��Ts) in myocardial and brain microvasculature. Few pathology studies have been conducted thus far and a precise mechanistic understanding is still needed. We propose the use of a combination of different synchrotron analysis techniques (X-ray micro- & nano-CT, fluorescence & SAXS/WAXS) for the characterization of the morphology, composition and structure of the MTs and ��Ts. In this specific experiment, we will apply X-ray nano-holotomography and fluorescence microscopy to obtain an unprecedented morphological and chemical characterization of the MTs and ��Ts at the level of individual thrombi, endothelial cells and possibly SARS-CoV-2 virions. (Read More)
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