2020 •
Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
Authors:
Matthew C. Wong, Sara Javornik Cregeen, Nadim J. Ajami, Joseph F. Petrosino
Abstract:SUMMARYA novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between (...) SUMMARYA novel coronavirus (nCoV-2019) was the cause of an outbreak of respiratory illness detected in Wuhan, Hubei Province, China in December of 2019. Genomic analyses of nCoV-2019 determined a 96% resemblance with a coronavirus isolated from a bat in 2013 (RaTG13); however, the receptor binding motif (RBM) of these two genomes share low sequence similarity. This divergence suggests a possible alternative source for the RBM coding sequence in nCoV-2019. We identified high sequence similarity in the RBM between nCoV-2019 and a coronavirus genome reconstructed from a viral metagenomic dataset from pangolins possibly indicating a more complex origin for nCoV-2019.(Read More)
Matthew C. Wong, Sara J. Javornik Cregeen, Nadim J. Ajami, Joseph F. Petrosino
Biorxiv ·
2020
Genetics |
Virology |
Computational biology |
We have placed cookies on your device to help make this website and the services we offer better. By using this site, you agree to the use of cookies. Learn more