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2020 • FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein.

Authors: Vitor Serrão, Jeffrey E. Lee

Abstract: In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an on-path intermediate. These insights into spike conformations will facilitate rational immunogen design.

External links: OpenAIRE

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FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein

Vitor Hugo B. Serrão, Jeffrey E. Lee

Cell Host & Microbe · 2020

Biophysics | Computational biology |

Open Access

Article