Authors:
A. Loenhoud, C. Boer, K. Wols, Y. Pijnenburg, A. Lemstra, F. Bouwman, N. Prins, P. Scheltens, R. Ossenkoppele, W. Flier
Abstract:
Additional file 6: Figure S1. Thresholds used for the dichotomization of cognitive domains and division of participants across cognitive profiles. Within the AD subsample (n=1,071), we dichotomized each cognitive domain score (i.e. memory, attention/executive functions, language and visuospatial functions), based on whether or not a domain’s W-score was considerably lower compared to an individual’s global cognition score. We used an optimal threshold between .250 and .500 for this dichotomization, and defined “optimality” in two differ (...)
Additional file 6: Figure S1. Thresholds used for the dichotomization of cognitive domains and division of participants across cognitive profiles. Within the AD subsample (n=1,071), we dichotomized each cognitive domain score (i.e. memory, attention/executive functions, language and visuospatial functions), based on whether or not a domain’s W-score was considerably lower compared to an individual’s global cognition score. We used an optimal threshold between .250 and .500 for this dichotomization, and defined “optimality” in two different ways: 1) the lowest number of participants in the multi-domain profile and the lowest sum of squared group sizes (threshold=.255), 2) the highest number of atypical variant AD cases (n=85) categorized into the language (i.e. for logopenic aphasia) or visuospatial cognitive profile (i.e. for PCA; n=.442). Note that neither thresholds (i.e. .255 or .442) resulted in all atypical variants being categorized into these two cognitive profiles, presumably because in advanced disease stages, several cognitive domains become affected. For many participants with an initial logopenic aphasia or PCA diagnosis, visuospatial/language may no longer have been predominant at study inclusion, causing them to be assigned to the multi-domain instead.
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