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2009 • Out of the box binding determines specificity of SH2 domain interaction.

Authors: Susanne Müller, Stefan Knapp, Stefan Knapp

Abstract: SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.

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Out of the Box Binding Determines Specificity of SH2 Domain Interaction

Susanne Müller, Stefan Knapp

Structure · 2009

Computational biology | Cell biology |

Open Access

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