Authors:
Montserrat Garcia-Closas, Sara Lindström, Kyriaki Michailidou, Marjanka K. Schmidt, Mark N. Brook, Nick Orr, Suhn K. Rhie, Elio Riboli, Loic Le Marchand, Julie E. Buring, Diana Eccles, Peter A. Fasching, Peter A. Fasching, Hiltrud Brauch, Hiltrud Br (...)
Montserrat Garcia-Closas, Sara Lindström, Kyriaki Michailidou, Marjanka K. Schmidt, Mark N. Brook, Nick Orr, Suhn K. Rhie, Elio Riboli, Loic Le Marchand, Julie E. Buring, Diana Eccles, Peter A. Fasching, Peter A. Fasching, Hiltrud Brauch, Hiltrud Brauch, Jenny Chang-Claude, Andrew K. Godwin, Heli Nevanlinna, Graham G. Giles, Angela Cox, John L. Hopper, Manjeet K. Bolla, Qin Wang, Joe Dennis, Ed Dicks, Nils Schoof, Stig E. Bojesen, Stig E. Bojesen, Diether Lambrechts, Annegien Broeks, Irene L. Andrulis, Pascal Guénel, Pascal Guénel, Barbara Burwinkel, Barbara Burwinkel, Antoinette Hollestelle, Olivia Fletcher, Robert Winqvist, Hermann Brenner, Arto Mannermaa, Ute Hamann, Alfons Meindl, Peter Devillee, Peter Devillee, Jan Lubinski, Vessela N. Kristensen, Anthony J. Swerdlow, Thilo Dörk, Keitaro Matsuo, Anna H. Wu, Paolo Radice, William Blot, Daehee Kang, Mikael Hartman, Suleeporn Sangrajrang, Chen-Yang Shen, Chen-Yang Shen, Melissa C. Southey, Daniel J. Park, Fleur Hammet, Jennifer Stone, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Julian Peto, Michael G. Schrauder, Arif B. Ekici, Matthias W. Beckmann, Isabel dos Santos Silva, Nichola Johnson, Helen R. Warren, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Federick Marme, Christof Sohn, Thérèse Truong, Thérèse Truong, Pierre Laurent-Puig, Pierre Kerbrat, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Roger L. Milne, Jose Ignacio Arias Perez, Primitiva Menéndez, Heiko Müller, Christa Stegmaier, Magdalena Lochmann, Christina Justenhoven, Christina Justenhoven, Yon Ko, Taru A. Muranen, Kristiina Aittomäki, Carl Blomqvist, Dario Greco, Tuomas Heikkinen, Hidemi Ito, Hiroji Iwata, Yasushi Yatabe, Natalia Antonenkova, Sara Margolin, Vesa Kataja, Jaana M. Hartikainen, Rosemary L. Balleine, David Van Den Berg, Patrick Neven, Anne Sophie Dieudonne, Karin Leunen, Anja Rudolph, Dieter Flesch-Janys, Paolo Peterlongo, Bernard Peissel, Loris Bernard, Janet E. Olson, Xianshu Wang, Kristen N. Stevens, Gianluca Severi, Laura Baglietto, Laura Baglietto, Catriona McLean, Gerhard A. Coetzee, Ye Feng, Brian E. Henderson, Fredrick R. Schumacher, Natalia Bogdanova, Martine Dumont, Cheng Har Yip, Nur Aishah Taib, Ching-Yu Cheng, Martha J. Shrubsole, Jirong Long, Katri Pylkäs, Arja Jukkola-Vuorinen, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, R.A.E.M. Tollenaar, Mieke Kriege, Maartje J. Hooning, Carolien H.M. van Deurzen, Wei Lu, Hui Cai, Sabapathy P. Balasubramanian, Simon S. Cross, Malcolm W.R. Reed, Hui Miao, Ching Wan Chan, Anna Jakubowska, Katarzyna Jaworska, Katarzyna Durda, Chia-Ni Hsiung, Pei Ei Wu, Alan Ashworth, Michael Jones, Daniel C. Tessier, Anna González-Neira, Guillermo Pita, M. Rosario Alonso, Daniel Vincent, Francois Bacot, Christine B. Ambrosone, Elisa V. Bandera, Esther M. John, Esther M. John, Gary K. Chen, Jennifer J. Hu, Jorge L. Rodriguez-Gil, Michael F. Press, Sandra Deming-Halverson, Sarah J. Nyante, Sue A. Ingles, Quinten Waisfisz, Enes Makalic, Daniel F. Schmidt, Minh Bui, Lorna Gibson, Bertram Müller-Myhsok, Rita K. Schmutzler, Rebecca Hein, Rebecca Hein, Norbert Dahmen, Lars Beckmann, Kamila Czene, Astrid Irwanto, Jianjun Liu, Clare Turnbull, Nazneen Rahman, Hanne Meijers-Heijboer, Fernando Rivadeneira, Curtis Olswold, Susan L. Slager, Robert Pilarski, Foluso O. Ademuyiwa, Irene Konstantopoulou, Nicholas G. Martin, Grant W. Montgomery, Dennis J. Slamon, Claudia Rauh, Michael P. Lux, Sebastian M. Jud, Thomas Brüning, JoEllen Weaver, Priyanka Sharma, Harsh B. Pathak, William J. Tapper, Lorraine Durcan, Rosario Tumino, Petra H.M. Peeters, Federico Canzian, Elisabete Weiderpass, Mattias Johansson, Kay-Tee Khaw, Laurence N. Kolonel, Constance Chen, Andrew H. Beck, Susan E. Hankinson, Susan E. Hankinson, Christine D. Berg, Robert N. Hoover, Jolanta Lissowska, Jonine D. Figueroa, Daniel I. Chasman, Mia M. Gaudet, David J. Hunter, Jacques Simard, Javier Benitez, Alison M. Dunning, Mark E. Sherman, Georgia Chenevix-Trench, Stephen J. Chanock, Christopher A. Haiman, Peter Kraft
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Abstract:
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-u (...)
Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
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