Authors:
Kenneth L Chiou, Mareike C Janiak, India Schneider-Crease, India Schneider-Crease, Sharmi Sen, Ferehiwot Ayele, Idrissa S. Chuma, Sascha Knauf, Sascha Knauf, Alemayehu Lemma, Anthony V. Signore, Anthony D'Ippolito, Belayneh Abebe, Abebaw Azanaw Haile (...)
Kenneth L Chiou, Mareike C Janiak, India Schneider-Crease, India Schneider-Crease, Sharmi Sen, Ferehiwot Ayele, Idrissa S. Chuma, Sascha Knauf, Sascha Knauf, Alemayehu Lemma, Anthony V. Signore, Anthony D'Ippolito, Belayneh Abebe, Abebaw Azanaw Haile, Fanuel Kebede, Peter J. Fashing, Peter J. Fashing, Nga Nguyen, Nga Nguyen, Colleen McCann, Marlys L. Houck, Jeffrey D. Wall, Andrew S. Burrell, Christina M. Bergey, Jeffrey Rogers, Jane E. Phillips-Conroy, Jane E. Phillips-Conroy, Clifford J. Jolly, Amanda D. Melin, Amanda D. Melin, Jay F. Storz, Amy Lu, Jacinta C. Beehner, Thore J. Bergman, Noah Snyder-Mackler
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Abstract:
AbstractSurvival at high altitude requires adapting to extreme conditions such as environmental hypoxia. To understand high-altitude adaptations in a primate, we assembled the genome of the gelada (Theropithecus gelada), an endemic Ethiopian monkey, and complemented it with population resequencing, hematological, and morphometric data. Unexpectedly, we identified a novel karyotype that may contribute to reproductive isolation between gelada populations. We also identified genomic eleme (...)
AbstractSurvival at high altitude requires adapting to extreme conditions such as environmental hypoxia. To understand high-altitude adaptations in a primate, we assembled the genome of the gelada (Theropithecus gelada), an endemic Ethiopian monkey, and complemented it with population resequencing, hematological, and morphometric data. Unexpectedly, we identified a novel karyotype that may contribute to reproductive isolation between gelada populations. We also identified genomic elements including protein-coding sequences and gene families that exhibit accelerated changes in geladas and may contribute to high-altitude adaptation. Our findings lend insight into mechanisms of speciation and adaptation while providing promising avenues for functional hypoxia research.
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