Abstract: ContinuousFlex allows analyzing single particle cryo electron microscopy data and in vitro and in situ cryo electron subtomogram data for continuous conformational variability of biomolecular complexes. It has been developed as a plugin of Scipion 3 software (https://github.com/scipion-em/scipion-em-continuousflex). Currently, ContinuousFlex provides HEMNMA, StructMap, HEMNMA-3D and TomoFlow methods. HEMNMA: Hybrid Electron Microscopy Normal Mode Analysis method to interpret heterogeneity of a set of single particle cryo-EM images in terms of c...
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