Abstract: Description: Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes joint inflammation, bone and cartilage destruction, and sometimes disability. The pathophysiology of RA, on the other hand, is multifactorial and, to a significant extent, unknown. Abnormal glycine metabolism is well established pathophysiological feature in RA [1] and the circulatory levels of glycine are largely reported to be elevated in RA [2]. Further, various clinical studies report the decreased circulatory levels of histidine in RA Patients. The low fre...
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