2019 •
The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins
Authors: Izzy Owen, Frank Shewmaker
Venue: International Journal of Molecular Sciences
Type: Publication
Abstract: Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid–liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.
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