Authors: Louise V. Wain, Nick Shrine, María Soler Artigas, A. Mesut Erzurumluoglu, Boris Noyvert, Lara Bossini-Castillo, Ma'en Obeidat, Amanda P. Henry, Michael A. Portelli, Robert J. Hall, Charlotte K. Billington, Tracy L. Rimington, Anthony G. Fenech, Catherine John, Tineka Blake, Victoria E. Jackson, Richard J. Allen, Bram P. Prins, Archie Campbell, David J. Porteous, Marjo-Riitta Järvelin, Matthias Wielscher, Alan James, Jennie Hui, Nicholas J. Wareham, Jing Hua Zhao, James F. Wilson, Peter K. Joshi, Beate Stubbe, Rajesh Rawal, Holger Schulz, Medea Imboden, Nicole Probst-Hensch, Stefan Karrasch, Christian Gieger, Ian J. Deary, Sarah E. Harris, Jonathan Marten, Igor Rudan, Stefan Enroth, Ulf Gyllensten, Shona M. Kerr, Ozren Polasek, Mika Kähönen, Ida Surakka, Veronique Vitart, Caroline Hayward, Terho Lehtimäki, Olli T. Raitakari, David M. Evans, A. John Henderson, Craig E. Pennell, Carol A. Wang, Peter D. Sly, Emily S. Wan, Robert Busch, Brian D. Hobbs, Augusto A. Litonjua, David Sparrow, Amund Gulsvik, Per Bakke, James D. Crapo, Terri H. Beaty, Nadia N. Hansel, Rasika A. Mathias, Ingo Ruczinski, Kathleen C. Barnes, Yohan Bossé, Philippe Joubert, Maarten van den Berge, Corry-Anke Brandsma, Peter D. Paré, Don D. Sin, David C. Nickle, Ke Hao, Omri Gottesman, Frederick E. Dewey, Shannon Bruse, David J. Carey, H. Lester Kirchner, Stefan Jonsson, Gudmar Thorleifsson, Ingileif Jonsdottir, Thorarinn Gislason, Kari Stefansson, Claudia Schurmann, Girish N. Nadkarni, Erwin P. Bottinger, Ruth J. F. Loos, Robin G. Walters, Zhengming Chen, Iona Y Millwood, Julien Vaucher, Om P Kurmi, Liming Li, Anna Hansell, Christopher E. Brightling, Eleftheria Zeggini, Michael H. Cho, Edwin K. Silverman, Ian Sayers, Gosia Trynka, Andrew P. Morris, David P. Strachan, Ian P. Hall, Martin D. Tobin

Venue: Nature Genetics

Type: Publication

Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (similar to 6 alleles) (95% confidence interval) = 1.24 (1... (read more)

DOI: 10.17863/cam.8791 (Found 2 versions)