Authors: Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R. Schreglmann, Luisa Sambati, Pilar Gómez-Garre, Claire Halsband, Giovanna Calandra-Buonaura, Astrid Daniela Adarmes-Gómez, Friederike Sixel-Döring, Corrado Zenesini, Chiara Pirazzini, Paolo Garagnani, Maria Giulia Bacalini, Kailash P. Bhatia, Pietro Cortelli, Brit Mollenhauer, Claudio Franceschi, Henry Houlden, Pietro Liò, Claudio Luchinat, Massimo Delledonne, Kevin Mills, Nancy L. Pedersen, Tiago Azevedo, Anna Bartoletti-Stella, Marta Bonilla-Toribio, Dolores Buiza-Rueda, Sabina Capellari, Mario Carriòn-Claro, Robert Clayton, Alessandra Dal Molin, Giovanna Maria Dimitri, Ivan Doykov, Cristina Giuliani, Sara Hägg, Jenny Hällqvist, Wendy Heywood, Ismael Huertas, Juulia Jylhävä, Miguel A. Labrador-Espinosa, Cristina Licari, Daniel Macias, Francesca Magrinelli, Juan Francisco Martín Rodríguez, Maria Giovanna Maturo, Giacomo Mengozzi, Gaia Meoni, Maddalena Milazzo, Christine Nardini, Maria Teresa Periñán-Tocino, Francesco Ravaioli, Claudia Sala, Simeon Spasov, Cristina Tejera-Parrado, Leonardo Tenori, Turano Paola, Dylan Williams, Luciano Xumerle, Elisa Zago, Marcella Broli, Patrizia De Massis, Rocio Escuela-Martin, Giovanni Fabbri, Anna Gabellini, Pietro Guaraldi, Stefania Macrì, Stefania Alessandra Nassetti, Cesa Lorella Maria Scaglione, Franco Valzania, Cilea Rosaria, Francesco Mignani, Rosario Vigo Ortega, Claudia Boninsegna, Silvia De Luca, Pablo Mir, Claudia Trenkwalder, Federica Provini

Venue: npj Parkinson's Disease

Type: Publication

Abstract: A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort. 340 PD siblings from three sites (Bologna, Seville, Kassel/Goettingen) underwen... (read more)

DOI: 10.17863/cam.76627 (Found 2 versions)