Authors: Ferdinand Marlétaz, Panos N. Firbas, Ignacio Maeso, Juan J. Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D. R. Wyatt, Elisa de la Calle-Mustienes, Stéphanie Bertrand, Demian Burguera, Rafael D. Acemel, Simon J. van Heeringen, Silvia Naranjo, Carlos Herrera-Úbeda, Ksenia Skvortsova, Sandra Jiménez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra Louis, Beatriz Albuixech-Crespo, Yann Le Petillon, Anthony Leon, Lucie Subirana, Piotr J. Balwierz, Paul Edward Duckett, Ensieh Farahani, Jean-Marc Aury, Sophie Mangenot, Patrick Wincker, Ricard Albalat, Èlia Benito-Gutiérrez, Cristian Cañestro, Filipe Castro, Salvatore D'Aniello, David E. K. Ferrier, Shengfeng Huang, Vincent Laudet, Gabriel A. B. Marais, Pierre Pontarotti, Michael Schubert, Hervé Seitz, Ildiko M. L. Somorjai, Tokiharu Takahashi, Olivier Mirabeau, Anlong Xu, Jr-Kai Yu, Piero Carninci, Juan Ramón Martínez-Morales, Hugues Roest Crollius, Zbynek Kozmik, Matthew T. Weirauch, Jordi Garcia-Fernàndez, Ryan Lister, Boris Lenhard, Peter W. H. Holland, Hector Escriva, José Luis Gómez-Skarmeta, Manuel Irimia

Venue: Nature

Type: Publication

Abstract: Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus (Branchiostoma lanceolatum) and characterize DNA methylation, chromatin accessibility, histone modifications and transcriptomes across multiple developmental stages and adult tissues to investigate the evolution of the regulation of the chordate genome. Comparisons with vertebrates identify an intermediate stage in the evolutio... (read more)

DOI: 10.17863/cam.36462 (Found 2 versions)