Authors: Brammerloh, M., Morawski, Friedrich, I., Reinert, T., Lange, C., Pelicon, P., Vavpetič, Jankuhn, S., Jäger, Alkemade, A., Balesar, R., Pine, K., Gavriilidis, F., Trampel, Reimer, E., Arendt, Weiskopf, N., Kirilina

Venue: NeuroImage

Type: Publication

Abstract: In Parkinson’s disease, the depletion of iron-rich dopaminergic neurons in nigrosome 1 of the substantia nigra precedes motor symptoms by two decades. Methods capable of monitoring this neuronal depletion, at an early disease stage, are needed for early diagnosis and treatment monitoring. Magnetic resonance imaging (MRI) is particularly suitable for this task due to its sensitivity to tissue microstructure and in particular, to iron. However, the exact mechanisms of MRI contrast in the substantia nigra are not well understood, hindering the d... (read more)

DOI: 10.17169/refubium-31555 (Found 2 versions)