Authors: Gärtner, Matti, Aust, Sabine, Bajbouj, Malek, Fan, Yan, Wingenfeld, Katja, Otte, Christian, Heuser-Collier, Isabella, Böker, Heinz, Hättenschwiler, Josef, Seifritz, Erich, Grimm, Simone, Scheidegger, Milan
Venue: European Neuropsychopharmacology
Type: Publication
Abstract: Abstract Converging evidence suggests that a single sub-anesthetic dose of ketamine can produce strong and rapid antidepressant effects in patients that do not respond to standard treatment. Despite a considerable amount of research investigating ketamine's mechanisms of action, the exact neuronal targets conveying the antidepressant effects have not been identified yet. Preclinical studies suggest that molecular changes induced by ketamine bring forward large-scale network reconfigurations that might relate to ketamine's antidepressant propert...
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DOI:
10.17169/refubium-31346
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