Abstract: BRCA2; DNA damage responses; Pyridostatin BRCA2; Respostes al dany de l'ADN; Piridostatina BRCA2; Respuestas al daño del ADN; Piridotatina The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication-associated DNA damage and genomic instability, a signature of BRCA1/2-mutated tumours. Targeted therapies against BRCA1/2-mutated tumours exploit this vulnerability by introducing additional DNA lesions. Because homologous recombination (HR) repair is abrogated in the absence of BRCA...
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Topics: 
Cancer research
Cell biology