Abstract: Carcinogenicity and mutagenicity are toxicological end points posing considerable concern for human health. Due to the cost in animal lives, time and money, alternative approaches to the rodent bioassay were designed based on: i) identification of mutations and ii) structure-activity relationships.Evidence on i) and ii) is summarized, covering 4 decades (1971 - 2010).A comprehensive, state-of-the-art perspective on alternatives to the carcinogenicity bioassay.Research to develop mutagenicity-based tests to predict carcinogenicity has generated ...
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Topics: 
Toxicology
Computational biology