Authors: Suzzi, Stefano, Ahrendt, Reiner, Hans, Stefan, Semenova, Svetlana A., Chekuru, Avinash, Wirsching, Paul, Kroehne, Volker, Bilican, Saygın, Sayed, Shady, Winkler, Sylke, Spieß, Sandra, Machate, Anja, Kaslin, Jan, Panula, Pertti, Brand, Michael
Venue: PLOS Genetics
Type: Publication
Abstract: Author summary Parkinson’s disease is the second most common degenerative disorder of the brain. Mutations of the LRRK2 gene are the most recurrent genetic cause of pathology, and are thought to result in a more active LRRK2 protein, a large enzyme whose biological function is unclear. Therefore, LRRK2 inhibitors are regarded as promising therapeutics. However, mouse models do not reproduce human pathology unless they also lack LRRK1, and there is evidence of dominant negative effects of LRRK2 mutations. Therefore, the characterization of rel...
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Topics: 
Genetics
Cell biology
Neuroscience
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