Abstract: Background Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present study, our aim was to establish an in vitro cell model based on patient-specific human neurons to study the pathomechanism of sporadic AD. Methods We compared neurons derived from induced pluripotent stem cell (iPSC) lines of patients with early-onset famili...
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Topics: 
Internal medicine
Endocrinology