Abstract: Abstract Background The two-stage design has become a standard tool in environmental epidemiology to model multi-location data. However, its standard form is rather inflexible and poses important limitations for modelling complex risks associated with environmental factors. In this contribution, we illustrate multiple design extensions of the classical two-stage method, all implemented within a unified analytic framework. Methods We extended standard two-stage meta-analytic models along the lines of linear mixed-effects models, by allowing loca...
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Topics: 
Operations research
Industrial engineering
Data mining