Authors: Nieuwenhuis, E.E.S., Schipper, H.S., Rakhshandehroo, M., Graaf, S.F.J. van de, Venken, K., Koppen, A., Stienstra, R., Prop, S., Meerding, J.M., Hamers, N., Besra, G., Boon, L, Elewaut, D., Prakken, A.B.J., Kersten, Boes, M.L., Kalkhoven, E.
Venue: Journal of Clinical Investigation
Type: Publication
Abstract: Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell-deficient mice on a low-fat diet, consider...
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Topics: 
Endocrinology
Internal medicine
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