Authors: Ece Kartal, Thomas S B Schmidt, Esther Molina-Montes, Sandra Rodríguez-Perales, Jakob Wirbel, Oleksandr M Maistrenko, Wasiu A Akanni, Bilal Alashkar Alhamwe, Renato J Alves, Alfredo Carrato, Hans-Peter Erasmus, Lidia Estudillo, Fabian Finkelmeier, Anthony Fullam, Anna M Glazek, Paulina Gómez-Rubio, Rajna Hercog, Ferris Jung, Stefanie Kandels, Stephan Kersting, Melanie Langheinrich, Mirari Márquez, Xavier Molero, Askarbek Orakov, Thea Van Rossum, Raul Torres-Ruiz, Anja Telzerow, Konrad Zych, Vladimir Benes, Georg Zeller, Jonel Trebicka, Francisco X Real, Nuria Malats, Peer Bork
Venue: Gut
Type: Publication
Abstract: Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. To explore the faecal and salivary microbiota as potential diagnostic biomarkers. We applied shotgun metagenomic and 16S rRNA amplicon sequencing to samples from a Spanish case-control study (n=136), including 57 cases, 50 controls, and 29 patients with chronic pancreatitis in the discovery phase, and from a German case-control study (n=76), in the validation phase. Faecal metagenomic classifiers performed much better than sa...
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Topics: 
Computational biology
Internal medicine
Bioinformatics
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