Authors: H.G. de Haan, A. van Hylckama Vlieg, L.A. Lotta, M.M. Gorski, P. Bucciarelli, I. Martinelli, T.P. Baglin, F. Peyvandi, F.R. Rosendaal, P. Amouyel, M. de Andrade, S. Basu, C. Berr, J.A. Brody, D. I Chasman, J.‐F. Dartigues, A.R. Folsom, M. Germain, J. Heit, J. Houwing‐Duitermaat, C. Kabrhel, P. Kraft, G. Le Gal, S. Lindström, R. Monajemi, P.‐E. Morange, B.M. Psaty, P.H. Reitsma, P.M. Ridker, L.M. Rose, N. Saut, E. Slagboom, D. Smadja, N.L. Smith, P. Suchon, W. Tang, K.D. Taylor, D.‐A. Trégouët, C. Tzourio, M.C.H. de Visser, L.‐C. Weng, K.L. Wiggins
Venue: Journal of Thrombosis and Haemostasis
Type: Publication
Abstract: International audience; Essentials Deep vein thrombosis (DVT) has a large unknown genetic component. We sequenced coding areas of 734 hemostasis-related genes in 899 DVT patients and 599 controls. Variants in F5, FGA-FGG, CYP4V2-KLKB1-F11, and ABO were associated with DVT risk. Associations in KLKB1 and F5 suggest a more complex genetic architecture than previously thought. SUMMARY: Background Although several genetic risk factors for deep vein thrombosis (DVT) are known, almost all related to hemostasis, a large genetic component remains unexp...
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Topics: 
Genetics
Internal medicine
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