Abstract: For the prediction of skin sensitization potential, the local lymph node assay (LLNA) is a fully validated alternative to guinea‐pig tests. More recently, information from LLNA dose–response analyses has been used to assess the relative potency of skin sensitizing chemicals. These data are then deployed for risk assessment and risk management. In this commentary, the utility and validity of these relative potency measurements are reviewed. It is concluded that the LLNA does provide a valuable assessment of relative sensitizing potency in th...
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Topics: 
Pharmacology
Toxicology
Immunology