Abstract: Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T‐cell‐mediated skin inflammation caused by repeated skin exposure to contact allergens, i.e. nonprotein chemicals called haptens. Allergic contact dermatitis, also referred to as contact hypersensitivity, is mediated by CD8+ T cells, which are primed in lymphoid organs during the sensitization phase and are recruited in the skin upon re‐exposure to the hapten. Subsets of CD4+ T cells endowed with suppressive activity are responsible for both the down‐re...
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