Authors: Adrià Aterido, María López-Lasanta, Francisco J. Blanco, Antonio Juan-Mas, María Luz García-Vivar, Alba Erra, Carolina Pérez-García, Simón Ángel Sánchez-Fernández, Raimon Sanmartí, Antonio Fernández-Nebro, Mercedes Alperi-López, Jesús Tornero, Ana M. Ortiz, Carlos Marras Fernandez-Cid, Núria Palau, Wenjing Pan, Miranda Byrne-Steele, Dmytro Starenki, Daniel Weber, Iván Rodríguez-Núñez, Jian Han, Richard M. Myers, Sara Marsal, Antonio Julià
Venue: SSRN Electronic Journal
Type: Publication
Abstract: ABSTRACTRheumatoid arthritis (RA) is an immune-mediated inflammatory disease characterized by a defective adaptive immune receptor repertoire (AIRR) that fails to distinguish self from non-self antigens. The AIRR is vast, encompassing four T cell receptor (TCR) and three B cell receptor (BCR) chains, each of which displays an extraordinary amino acid sequence variability in the antigen-binding site. How the concerted action of T and B cell clones is associated with the development and clinical evolution of immune-mediated diseases is still not ...
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Topics: 
Immunology
Genetics
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