BIP! Finder - Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2

2009 • Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2

Authors: Takayuki, Katoh, Yuriko, Sakaguchi, Kenjyo, Miyauchi, Takeo, Suzuki, Shin-Ichi, Kashiwabara, Tadashi, Baba, Tsutomu

Venue: Genes & Development

Type: Publication

Abstract: The steady-state levels of microRNAs (miRNAs) and their activities are regulated by the post-transcriptional processes. It is known that 3′ ends of several miRNAs undergo post-dicing adenylation or uridylation. We isolated the liver-specific miR-122 from human hepatocytes and mouse livers. Direct analysis by mass spectrometry revealed that one variant of miR-122 has a 3′-terminal adenosine that is introduced after processing by Dicer. We identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3′-term... (read more)

Topics: Molecular biology Cell biology

DOI: 10.1101/gad.1761509

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External links: Crossref OpenAIRE

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