Abstract: AbstractProtein phase separation is increasingly understood to be an important mechanism of biological organization and biomaterial formation. Intrinsically disordered protein regions (IDRs) are often significant drivers of protein phase separation. A number of protein phase separation prediction algorithms are available, with many specific for particular classes of proteins and others providing results that are not amenable to interpretation of contributing biophysical interactions. Here we describe LLPhyScore, a new predictor of IDR-driven ph...
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Topics: 
Artificial intelligence
Machine learning
Chemical physics