Authors: Heidrun, Ellinger-Ziegelbauer, Jennifer M, Fostel, Chinami, Aruga, Daniel, Bauer, Eric, Boitier, Shibing, Deng, Donna, Dickinson, Anne-Celine, Le Fevre, Albert J, Fornace, Olivier, Grenet, Yizhong, Gu, Jean-Christophe, Hoflack, Masako, Shiiyama, Roger, Smith, Ronald D, Snyder, Catherine, Spire, Gotaro, Tanaka, Jiri, Aubrecht
Venue: Toxicological Sciences
Type: Publication
Abstract: The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens. However, it features a low specificity and provides only limited mechanistic information required for risk assessment of positive findings. This is especially important in case of positive findings in the in vitro chromosome damage assays, because chromosome damage may be also induced secondarily to cell death. An increasing body of evidence indicates that toxicogenomic analysis of cellular stress responses provides an insight into mechanisms of action o...
(read more)
Topics: 
Computational biology
Genetics
Loading (it may take a couple of seconds)...
Loading (it may take a couple of seconds)...