Authors: A, Pessina, B, Albella, M, Bayo, J, Bueren, P, Brantom, S, Casati, C, Croera, G, Gagliardi, Foti, R, Parchment, D, Parent-Massin, Schoeters, Y, Sibiril, Van Den Heuvel, L, Gribaldo
Venue: Toxicological Sciences
Type: Publication
Abstract: In a previous study of prevalidation, a standard operating procedure (SOP) for two independent in vitro tests (human and mouse) had been developed, to evaluate the potential hematotoxicity of xenobiotics from their direct and the adverse effects on granulocyte-macrophages (CFU-GM). A predictive model to calculate the human maximum tolerated dose (MTD) was set up, by adjusting a mouse-derived MTD for the differential interspecies sensitivity. In this paper, we describe an international blind trial designed to apply this model to the clinical neu...
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Topics: 
Pharmacology
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