Abstract: Well-established in vitro methods for testing the genotoxic potency of chemicals-such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test-show a high false-positive rate for predicting in vivo genotoxicity and carcinogenicity. Thus, there is a need for more reliable in vitro assays. We investigated whether gene expression profiling in metabolically competent primary mouse hepatocytes is capable of discriminating true genotoxic (GTX) compounds from false-positive genotoxic (FP-GTX) com...
(read more)
Topics: 
Genetics
Computational biology
Molecular biology