Abstract: Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are abundant in all species. They play critical roles in many cellular processes, including transcription/translation regulation, cell cycle regulation, mRNA processing, scaffolding, apoptosis, and assembly of large protein complexes or membraneless organelles. IDPs/IDRs usually recognize their biological targets via short recognition segments. Although the recognition segments are enriched in hydrophobic residues and IDPs/IDRs rely on hydrophobic contacts to i...
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Topics: 
Biophysics
Nanotechnology
Computational biology