Authors: Sandile Cele, Laurelle Jackson, David S. Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel G. Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M. Blackburn, Bernadett I. Gosnell, Salim S. Abdool Karim, Willem Hanekom, Mary-Ann Davies, Marvin Hsiao, Darren Martin, Koleka Mlisana, Constantinos Kurt Wibmer, Carolyn Williamson, Denis York, Rohen Harrichandparsad, Kobus Herbst, Prakash Jeena, Thandeka Khoza, Henrik Kløverpris, Alasdair Leslie, Rajhmun Madansein, Nombulelo Magula, Nithendra Manickchund, Mohlopheni Marakalala, Matilda Mazibuko, Mosa Moshabela, Ntombifuthi Mthabela, Kogie Naidoo, Zaza Ndhlovu, Thumbi Ndung’u, Nokuthula Ngcobo, Kennedy Nyamande, Vinod Patel, Theresa Smit, Adrie Steyn, Emily Wong, Anne von Gottberg, Jinal N. Bhiman, Richard J. Lessells, Mahomed-Yunus S. Moosa, Miles P. Davenport, Tulio de Oliveira, Penny L. Moore, Alex Sigal
Venue: Nature
Type: Publication
Abstract: AbstractThe emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-con...
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