Abstract: Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signalling, a core group of transcription factors have essential roles in this process by directly activating and repressing specific genes. Many of these transcription factors also function again, but controlling different genes, in later T cell development. Here, we review how these transcription factors work to change the activities of specific genomic loci during earl...
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Topics: 
Genetics
Cell biology