Abstract: Epigenetically mediated transcriptional-silencing events occur at key genes during the earliest stages of tumorigenesis. Understanding how these events alter cell signal transduction and function can provide useful clues to improve cancer detection, prevention and therapy. Chromatin alterations have been associated with all stages of tumour formation and progression. The best characterized are epigenetically mediated transcriptional-silencing events that are associated with increases in DNA methylation — particularly at promoter regions of ge...
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Topics: 
Cancer research
Genetics