Authors: A P, Deveau, A M, Forrester, A J, Coombs, G S, Wagner, C, Grabher, I C, Chute, D, Léger, M, Mingay, G, Alexe, V, Rajan, R, Liwski, Hirst, K, Steigmaier, S M, Lewis, A T, Look, J N, Berman
Venue: Leukemia
Type: Publication
Abstract: Acute myeloid leukemia (AML) occurs when multiple genetic aberrations alter white blood cell development, leading to hyperproliferation and arrest of cell differentiation. Pertinent animal models link in vitro studies with the use of new agents in clinical trials. We generated a transgenic zebrafish expressing human NUP98-HOXA9 (NHA9), a fusion oncogene found in high-risk AML. Embryos developed a preleukemic state with anemia and myeloid cell expansion, and adult fish developed a myeloproliferative neoplasm (MPN). We leveraged this model to sho...
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Topics: 
Cancer research
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