1984 •
Malignant transformation of early passage rodent cells by a single mutated human oncogene
Authors: D A, Spandidos, N M, Wilkie
Venue: Nature
Type: Publication
Abstract: When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal Ha-ras-1 proto-oncogene only induces immortalization. Therefore, mutated Ha-ras-1 does not require a cooperating gene to trigger malignant conversion and ras genes may be involved in the process of tumorigenesis at an earlier stage than previously suspected.
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