Abstract: Conventional models of the immune response are based on distinguishing self and non‐self. However, we consider that the more recently proposed ‘danger’ model may be an illuminating alternative for studying allergic contact dermatitis. In this model, an antigenic signal on its own would tend to produce tolerance. In contrast, in the presence of a ‘danger’ signal, which, in the case of allergic contact dermatitis, we suggest is usually cutaneous irritancy, the immune system would become activated, leading first to the induction of sensi...
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Topics: 
Immunology
Dermatology