Abstract: The dysregulation of metal homeostasis is reported to enhance the aggregation of tau, a key neuronal microtubule-associated protein. Herein, we found that ferric (Fe3+) ions enhanced tau aggregation. Fe3+ and Al3+ induced tau aggregation while several trivalent metal ions such as Cr3+, La3+, and V3+ had no discernable effect on tau aggregation. Fe3+ reduced the critical concentration of tau required for the liquid-liquid phase separation (LLPS); however, Cr3+, La3+, and V3+ did not affect tau droplet formation. Dynamic light scattering, atomic ...
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Topics: 
Biophysics
Crystallography