Authors: Simon, Maria S., Schiweck, Carmen, Arteaga-Henríquez, Gara, Poletti, Sara, Haarman, Bartholomeus C.M., Dik, Wim A., Schwarz, Markus, Vrieze, Elske, Mikova, Olya, Joergens, Silke, Musil, Richard, Claes, Stephan, Baune, Bernhard T., Leboyer, Marion, Benedetti, Francesco, Furlan, Roberto, Berghmans, Raf, de Wit, Harm, Wijkhuijs, Annemarie, Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Type: Publication
Abstract: BACKGROUND: The macrophage theory of depression states that macrophages play an important role in Major Depressive Disorder (MDD). METHODS: MDD patients (N = 140) and healthy controls (N = 120) participated in a cross-sectional study investigating the expression of apoptosis/growth and lipid/cholesterol pathway genes (BAX, BCL10, EGR1, EGR2, HB-EGF, NR1H3, ABCA1, ABCG1, MVK, CD163, HMOX1) in monocytes (macrophage/microglia precursors). Gene expressions were correlated to a set of previously determined and reported inflammation-regulating genes ...
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