Abstract: The effect of the mitogen bombesin on pHi in cells of the chick otic vesicle was studied using dual wavelength microspectrofluorimetric techniques. The results show that the bombesin did not produce an immediate alkalinization in quiescent otic vesicle cells nor a long‐term change in pHi in vesicles reactivated to grow in culture. The recovery of pHi from an acid load, caused by an NH4 pulse, involved both Na+/H+ exchange and Na+:HCO3 influx mechanisms, neither of which was influenced by bombesin. These observations do not fit with a general ...
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Topics: 
Molecular biology
Cell biology
Internal medicine