Abstract: Publisher Summary This chapter discusses the advances made in understanding the mechanisms of action of chemical carcinogens in the light of the recent evidence that oncogenes are directly implicated in the process of tumor development. It discusses various model systems used to address the question of cell transformation in vivo. The process of carcinogenesis in cell culture is compared with the various stages of tumor development in vivo . It is noted that oncogenes provide potential targets for activation by carcinogens. Indeed, the full spe...
(read more)
Topics: 
Cancer research
Genetics
Cell biology