Abstract: In this study we investigated the effects of maternal Δ9-tetrahydrocannabinol on the developing serotonergic system. A daily dose of Δ9-tetrahydrocannabinol (5 mg/kg body weight) was administered p.o. to pregnant rats from gestational day 5 to postnatal day 1. Levels of indolamines were measured in four brain areas of the offspring on the day before or after birth. Levels of indolamines depended on the cerebral area, sex and pre- or postnatal age. Maternal exposure to Δ9-tetrahydrocannabinol decreased diencephalic levels of 5-hydroxytryptami...
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Topics: 
Internal medicine
Endocrinology
Physiology