Authors: Gouliarmou, V. (Varvara), Lostia, A. M. (Alfonso Maria), Coecke, S. (Sandra), Bernasconi, C. (Camilla), Bessems, J. (Jos), Dorne, J. L. (Jean Lou), Ferguson, S. (Stephen), Testai, E. (Emanuela), Remy, U. G. (Ursula Gundert), Houston, J. B. (J. Brian), Monshouwer, M. (Mario), Nong, A. (Andy), Pelkonen, O. (Olavi), Morath, S. (Siegfried), Wetmore, B. A. (Barbara A.), Worth, A. (Andrew), Zanelli, U. (Ugo), Zorzoli, M. C. (Maria Chiara), Whelan, M. (Maurice)
Venue: Toxicology in Vitro
Type: Publication
Abstract: Abstract Hepatic metabolic clearance is one of the most important factors driving the overall kinetics of chemicals including substances used in various product categories such as pesticides, biocides, pharmaceuticals, and cosmetics. A large number of in vitro systems from purified isozymes and subcellular organelles to hepatocytes in simple cultures and in complex scaffold setups are available for measuring hepatic metabolic clearance for different applications. However, there is currently no approach for systematically characterising and comp...
(read more)
Topics: 
Biochemical engineering
Computational biology
Biological system
Loading (it may take a couple of seconds)...
Loading (it may take a couple of seconds)...