Abstract: Neurons require unique subcellular compartmentalization to function efficiently. Formed from proteins and RNAs through liquid-liquid phase separation, membraneless organelles have emerged as one way in which cells form distinct, specialized compartments in the absence of lipid membranes. We first discuss membraneless organelles that are common to many cell types as well as those that are specific to neurons. Interestingly, many proteins associated with neurodegenerative disease are found in membraneless organelles, particularly stress and trans...
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Topics: 
Cell biology