Abstract: article i nfo Article history: Piperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350 mg/kg, i.p.) was administered 30 min after piperine (2.5, 5, 10 and 20 mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and per- centage of survivals. These parameters were also increased in the pilocarpine groups pretreated with atro- pine plus piperine (10 and 2.5 mg/kg, respectively), as related to the pilocarpin...
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Topics: 
Pharmacology
Anesthesia