Abstract: Summary Early in development, primordial germ cells (PGCs) are set aside from somatic cells and acquire a unique gene-expression program [1]. The mechanisms underlying germline-specific gene expression are largely unknown. Nanos expression is required during germline development [2–5] and is posttranscriptionally restricted to PGCs [4, 6–8]. Here we report that the microRNA miR-430 targets the 3′ untranslated region (UTR) of nanos1 during zebrafish embryogenesis. A miR-430 target site within the nanos1 3′ UTR reduces poly(A) tail length...
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Topics: 
Genetics
Cell biology